Is the immunomodulatory effect of MSCs triggered through monocytes?
Intravenous infusion of mesenchymal stem cells (MSCs) commonly leads to rapid cell entrapment and death in the microvasculature of the lung within 24 hours. however, within this short period, they manage to exhibit powerful immunomodulatory capabilities and therapeutic benefits. Research done at Rotterdam detected dead MSCs within monocytic cells in the lung and liver and also disseminated throughout the body. It is suggested that the monocytes undergo change and exhibit mult