"Stem Cell Medicine Ltd. (SCM) has licensed an innovative exosomes based technology for the treatment of neurodegenerative and neuropsychiatric indications, specifically, autism spectrum disorder (ASD). The treatment is based on vesicles, exosomes, derived from adult stem cells (MSC-exo) that are administered intranasally. The technology was developed by Professor Dani Offen, Sackler School of Medicine, Sagol School of Neurosciences Tel Aviv University.
In efficacy studies conducted in preclinical models, intranasal treatment with MSC-exo was associated with a significant improvement in the several autistic behavioral phenotypes. Social interaction and ultrasonic vocalizations increased, repetitive behaviors were reduced and there was a significant improvement in maternal behaviors of pup retrieval. No negative symptoms were observed."