Exosomes in Therapy of Osteoarthritis
" the characteristics of exosomes indicate its potential value in the treatment of OA. First, exosomes have a relatively long life span. Exosomes can be isolated from various body fluids and stored at −80°C for a long time. Secondly, exosomes carry bioactive substances, including mRNAs, miRNAs, lncRNAs and proteins, to protect them from enzymatic degradation, which indicates that exosomes have the potential to deliver nucleic acid and protein drugs to target cells. Third, exosomes can be further modified to carry specific drugs to meet the needs of specific treatment regimens. In this review, we provide evidence of exosomes in the direct and indirect regulation of OA pathogenesis, with particular emphasis on the roles of miRNAs and lncRNAs"
"However, the potential feasibility and targets of exosomes as OA treatment vectors are not fully understood, and the basic and clinical research still has a long way"
Chenggui Miao, Wanwan Zhou, Xiao Wang and Jihong Fang. (2021) The Research Progress of Exosomes in Osteoarthritis, With Particular Emphasis on the Mediating Roles of miRNAs and lncRNAs. Frontiers in Pharmacology. doi: 10.3389/fphar.2021.685623