- drjmohan
Mesenchymal Stem/Stromal Cell Therapy for Renal Artery Stenosis
Renal artery stenosis (RAS) results in "hypertension and post-stenotic kidney damage, which may become irresponsive to restoration of arterial patency. Rather than mere losses of blood flow or oxygen supply, irreversible intrarenal microvascular rarefaction, tubular injury, and
interstitial fibrosis are now attributed to intrinsic pathways activated within the kidney, focusing attention on the kidney parenchyma as a therapeutic target. Several regenerative approaches involving the delivery of reparative cells or products have achieved kidney repair in experimental models of RAS and the delivery of mesenchymal stem/stromal cells (MSCs) has already been translated to human subjects with RAS with promising results."
Image from Wikipedia.
"Leman L.O. (2021) Cell-based regenerative medicine for renovascular disease. Trends in Molecular Medicine. DOI:https://doi.org/10.1016/j.molmed.2021.06.004