A recently published paper demonstrated that intrapancreatic‐injection of concentrated hMSC‐conditioned media (CM) stimulated islet regeneration without requiring cell transfer. Initial analyses discovered that intrapancreatic‐injection of concentrated conditioned medium derived from hBM-MSCs stimulated islet regeneration in a dose-dependent manner without the need for cell transfer. Overall, the authors observed significantly reduced hyperglycemia, increased levels of circulating serum insulin, and improved glucose tolerance in a streptozotocin‐treated murine model of diabetes.
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