"Stem cells utilized for DFU wound healing are a promising treatment modality as
their therapeutic properties address many facets of the underlying pathophysiology
of the impaired wound healing inherent in DFU. It has been shown that stem cells are
able to mobilize and home to ischemic and wounded tissues, where they then embark
on a cascade of pro-wound healing strategies. They are able to synthesize and secrete
cytokines, which recruit other types of cells needed for the reconstruction of the
wound bed, secrete growth factors, modulate the tissue immune response, assist in
remodeling of the extracellular matrix, and promote angiogenesis and neuroregeneration.
Taken together, stem cells utilize a vast array of tactics to promote wound
Quiroz H.J., Liu Z, & Velazquez O.C, (2021) Stem Cell Therapy for Diabetic Foot Ulcers. In Navarro T.P., Lopes L.L.N.M. & Dardik A. (Eds) . Stem Cell Therapy for Vascular Diseases. (pp. 155-172). Switzerland: Springer Nature.