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Stem Cells for Diabetic Foot Ulcers (DFU)

"Stem cells utilized for DFU wound healing are a promising treatment modality as

their therapeutic properties address many facets of the underlying pathophysiology

of the impaired wound healing inherent in DFU. It has been shown that stem cells are

able to mobilize and home to ischemic and wounded tissues, where they then embark

on a cascade of pro-wound healing strategies. They are able to synthesize and secrete

cytokines, which recruit other types of cells needed for the reconstruction of the

wound bed, secrete growth factors, modulate the tissue immune response, assist in

remodeling of the extracellular matrix, and promote angiogenesis and neuroregeneration.

Taken together, stem cells utilize a vast array of tactics to promote wound


Quiroz H.J., Liu Z, & Velazquez O.C, (2021) Stem Cell Therapy for Diabetic Foot Ulcers. In Navarro T.P., Lopes L.L.N.M. & Dardik A. (Eds) . Stem Cell Therapy for Vascular Diseases. (pp. 155-172). Switzerland: Springer Nature.


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