"Research findings suggest that stem cell-based therapy in DFU is promising in the field
of regenerative medicine. Their therapeutic mechanisms include promoting angiogenesis,
secreting paracrine factors, stimulating vascular differentiation, suppressing inflammation,
improving collagen deposition, and immunomodulation. These results prove that stem cellbased therapy is effective in wound healing and decreases amputation rates."
"Studies have also reported that different functions and properties of stem cells including
angiogenesis, multipotent state, differentiation, metabolism, and immunomodulation are
impaired in patients with diabetes. Therefore, employing allogeneic rather than autologous,
diabetic, and impaired stem cells could be a better alternative in cell therapy to promote
DFU healing. As for the administration route of stem cell therapy in DFU, it has been
reported that intramuscular and topical administration are safer and more effective than
intravascular administration."
El Hage, R.; Knippschild, U.; Arnold, T.; Hinterseher, I. Stem Cell-Based Therapy: A Promising Treatment for Diabetic Foot Ulcer. Biomedicines 2022, 10, 1507. https://doi.org/10.3390/biomedicines10071507