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Advances in stem cell therapy for erectile dysfunction

"Stem cell (SC) application is a promising area of research in regenerative medicine, with the potential to treat, prevent, and cure disease. In recent years, the number of studies focusing on SCs for the treatment of erectile dysfunction (ED) and other sexual dysfunctions has increased significantly.

Expert opinion: Combination treatment offers better results than monotherapy to improve pathological changes in diabetic ED. Regenerative medicine is a promising approach for the maintenance of sexual health and erectile function later in life. Cavernous nerve regeneration and vascular recovery employing SC treatment may be focused on radical prostatectomy-induced ED. Notwithstanding, there are a number of hurdles to overcome before SC-based therapies for ED are considered in clinical settings. Paracrine action, not cellular differentiation, appears to be the principal mechanism of action underlying SC treatment of ED. Intracavernosal injection of a single SC type should be the choice protocol for future clinical trials."

Phase I and phase II clinical trials for the treatment of male sexual dysfunction—a systematic review of the literature

The authors conducted a systematic review of the literature including both published and ongoing phase I and II registered trials focused on medical treatment of Erectile Dysfunction, Premature Ejaculation, and Peyronie's Disease during the last 5 years. A total of 35 trials were identified. Most studies (63%) investigated ED treatments and 26% were still ongoing. Stem cells (SCs) therapy was assessed in 28% of trials.


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