• drjmohan

Benefits of Umbilical Cord Tissue Mesenchymal Stem Cells (UCT-MSC)

"UCT is a rich source of MSC and can be used as an alternative to BM- or adipose tissue (AT)-derived MSC. UCT-MSC may be isolated from the placenta, the perivascular space, and the Wharton’s jelly present in the umbilical cord stroma and yields higher numbers of MSC when compared to BM or AT. Besides, UCT-MSC have higher proliferative potential than BM- and AT-MSC and express higher amounts of cytokines and hematopoietic growth factors, such as G-CSF, GM-CSF, LIF, IL-1α, IL-6, and IL-8. Of note, its proangiogenic capacity is independent of

VEGF-A. As a source of perinatal cells, UCT-MSC express markers of pluripotency higher than postnatal tissue, but lesser than ESC, and are not known to induce tumorigenesis. Its therapeutic effects in preclinical and clinical studies, including vascular diseases, encourage further studies to pursue the clinical use of UCT-MSC."

Arutyunyan I, Elchaninov A, Makarov A, et al. Umbilical cord as prospective source for

mesenchymal stem cell-based therapy. Stem Cells Int. 2016;2016:ID 6901286.


Recent Posts

See All

Chronic heart failure is the most common reason for hospital admissions and one of the most frequent causes of death in the western world. Scientists around the world are therefore working on strategi

"Autoimmune diseases, chronic in nature, are generally hard to alleviate. Present long-term treatments with available drugs such as steroids, immune-suppressive drugs, or antibodies have several debil