• Shashi

Impact of Donor Age on Functionality of Induced Pluripotent Stems (iPSCs)

Updated: Apr 11, 2019

"Induced pluripotent stem cells (iPSCs) avoid many of the restrictions that hamper the application of human embryonic stem cells: limited availability of source material due to legal restrictions in some countries, immunogenic rejection and ethical concerns. iPSCs seem ideal to tackle the two biggest tasks of regenerative medicine: degenerative diseases with genetic cause (e.g., Duchenne’s muscular dystrophy) and organ replacement in age-related diseases (e.g., end-stage heart or renal failure), especially in combination with recently developed gene-editing tools."


It was traditionally believed that iPSCs from an old individual would not be a viable option for autologous transplantation due to senescence. Instead, typical signs of cellular ageing are reverted in the process of iPSC reprogramming, and iPSCs from older donors do not show diminished differentiation potential nor do iPSC-derived cells from older donors suffer early senescence or show functional impairments when compared with those from younger donors.


#IPSC #donorage #impactonfunctionality


Age Is Relative—Impact of Donor Age on Induced Pluripotent Stem Cell-Derived Cell Functionality

DOI=10.3389/fcvm.2018.00004

5 views

Recent Posts

See All

Chronic heart failure is the most common reason for hospital admissions and one of the most frequent causes of death in the western world. Scientists around the world are therefore working on strategi

"Autoimmune diseases, chronic in nature, are generally hard to alleviate. Present long-term treatments with available drugs such as steroids, immune-suppressive drugs, or antibodies have several debil